Does central nervous system dysfunction underlie patellofemoral pain in young females? Examining brain functional connectivity in association with patient‐reported outcomes

Patellofemoral pain (PFP) refers to significant retro‐ or peri‐patellar pain of the knee that is not directly associated with an obvious structural abnormality. PFP is a highly prevalent knee disorder (>20% of population). Females are 2–10 times more likely to develop PFP than males, and PFP detrimentally afflicts those who are physically active. Traditional and […]

Muscle strength explains the protective effect of physical activity against COVID-19 hospitalization among adults aged 50 years and older.

The risk factors of COVID-19 include not only older age, male sex, and underlying chronic conditions (i.e., obesity, cardiovascular disease, lung disease, kidney disease, diabetes, and cancer), but also lower physical fitness, as indexed by weaker muscle strength, by lower maximal exercise capacity or lower walking speed. During the current pandemic, insufficient attention has been […]

Using an erythrocyte fatty acid fingerprint to predict risk of all-cause mortality: the Framingham Offspring Cohort

The Framingham Heart Study provided unique insights into cardiovascular disease (CVD) risk factors and ledto the development of the Framingham Risk Score based on 8 baseline standard risk factors—that is, age, sex, smoking, hypertension treatment, diabetes status, systolic blood pressure, total cholesterol, and HDL cholesterol. In addition to the standard risk factors, biomarkers integrating lifestyle […]

Running Biomechanics Before Injury and 1 Year After Anterior Cruciate Ligament Reconstruction in Division I Collegiate Athletes

After anterior cruciate ligament (ACL) reconstruction (ACLR), athletes demonstrate significant alterations in surgical limb running biomechanics as compared with the nonsurgical limb and healthy controls. These changes include decreased peak knee flexion angle and knee flexion excursion, decreased peak knee extensor moment, decreased patellofemoral joint force, increased initial impact forces, and decreased peak vertical ground […]

The influence of swing leg motion on maximum running speed

Maximal running speed in humans demonstrates great variability. The speeds of over 12 m/s have been recorded by elite male athletes in competition, which is significantly faster than the reported values for the majority of physically active men and women. This prompts the question of what allows some humans to run so much faster than […]

Effects of Overtraining Status on the Cortisol Awakening Response—Endocrine and Metabolic Responses on Overtraining Syndrome (EROS-CAR)

Cortisol is the predominant circulating glucocorticoid released in response to stressful stimuli. In addition to acute stress responses, cortisol is one of the major circadian regulating hormones, and it exhibits a robust and distinct circadian and diurnal profile. Cortisol concentrations are typically greatest in the early morning, before decreasing across the daytime period and reaching […]

Effect of shoe cushioning on landing impact forces and spatiotemporal parameters during running: results from a randomized trial including 800+ recreational runners

Running footwear is potentially an extrinsic risk factor that may modify the training load an athlete can tolerate before incurring a running-related injury. However, there is currently only limited evidence on the relationship between shoe features and running-related injury risk. Amongst others, it is currently unclear to what extent shoe cushioning influences injury risk. A […]