Does central nervous system dysfunction underlie patellofemoral pain in young females? Examining brain functional connectivity in association with patient‐reported outcomes
Patellofemoral pain (PFP) refers to significant retro‐ or peri‐patellar pain of the knee that is not directly associated with an obvious structural abnormality. PFP is a highly prevalent knee disorder (>20% of population). Females are 2–10 times more likely to develop PFP than males, and PFP detrimentally afflicts those who are physically active. Traditional and […]
Muscle strength explains the protective effect of physical activity against COVID-19 hospitalization among adults aged 50 years and older.
The risk factors of COVID-19 include not only older age, male sex, and underlying chronic conditions (i.e., obesity, cardiovascular disease, lung disease, kidney disease, diabetes, and cancer), but also lower physical fitness, as indexed by weaker muscle strength, by lower maximal exercise capacity or lower walking speed. During the current pandemic, insufficient attention has been […]
The Role of the Skeletal Muscle Secretome in Mediating Endurance and Resistance Training Adaptations.
Exercise, in the form of endurance or resistance training, leads to specific molecular and cellular adaptions not only in skeletal muscles, but also in many other organs such as the brain, liver, fat or bone. These adaptations are mediated by the production and release of signaling molecules, myokines, from skeletal muscle. Most studies have so […]
Using an erythrocyte fatty acid fingerprint to predict risk of all-cause mortality: the Framingham Offspring Cohort
The Framingham Heart Study provided unique insights into cardiovascular disease (CVD) risk factors and ledto the development of the Framingham Risk Score based on 8 baseline standard risk factors—that is, age, sex, smoking, hypertension treatment, diabetes status, systolic blood pressure, total cholesterol, and HDL cholesterol. In addition to the standard risk factors, biomarkers integrating lifestyle […]
Running Biomechanics Before Injury and 1 Year After Anterior Cruciate Ligament Reconstruction in Division I Collegiate Athletes
After anterior cruciate ligament (ACL) reconstruction (ACLR), athletes demonstrate significant alterations in surgical limb running biomechanics as compared with the nonsurgical limb and healthy controls. These changes include decreased peak knee flexion angle and knee flexion excursion, decreased peak knee extensor moment, decreased patellofemoral joint force, increased initial impact forces, and decreased peak vertical ground […]
Low Horizontal Force Production Capacity during Sprinting as a Potential Risk Factor of Hamstring Injury in Football.
Hamstring injuries are the most prevalent injuries in football, with an average of 22% of players sustaining at least one hamstring injury during a season. The majority of hamstring injuries (~70%) occur during high-speed sprinting actions. Consequently, it seems logical to expect sprinting to be a key parameter in football from both performance and hamstring […]
Maximal running speed in humans demonstrates great variability. The speeds of over 12 m/s have been recorded by elite male athletes in competition, which is significantly faster than the reported values for the majority of physically active men and women. This prompts the question of what allows some humans to run so much faster than […]
The ability to rapidly change direction is an important action associated with successful performance in multidirectional sports. For example, soccer players can perform ~600 cuts of 0–90° and ~100 turns of 90– 180° during matches. A change of direction (COD) typically involves an athlete adopting a lateral foot plant to change their base of support […]
Effects of Overtraining Status on the Cortisol Awakening Response—Endocrine and Metabolic Responses on Overtraining Syndrome (EROS-CAR)
Cortisol is the predominant circulating glucocorticoid released in response to stressful stimuli. In addition to acute stress responses, cortisol is one of the major circadian regulating hormones, and it exhibits a robust and distinct circadian and diurnal profile. Cortisol concentrations are typically greatest in the early morning, before decreasing across the daytime period and reaching […]
Effect of shoe cushioning on landing impact forces and spatiotemporal parameters during running: results from a randomized trial including 800+ recreational runners
Running footwear is potentially an extrinsic risk factor that may modify the training load an athlete can tolerate before incurring a running-related injury. However, there is currently only limited evidence on the relationship between shoe features and running-related injury risk. Amongst others, it is currently unclear to what extent shoe cushioning influences injury risk. A […]